BDBM50234157 CHEMBL4089227

SMILES Cn1nc(nc1C1(CC1)c1ccccc1)-c1cnc(N)c(n1)-c1nnc(o1)C(C)(C)C

InChI Key InChIKey=SVVZLGTVPFWKPA-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50234157   

LigandPNGBDBM50234157(CHEMBL4089227)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of recombinant human His6-tagged PI3K p110delta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2019
Entry Details Article
PubMed
LigandPNGBDBM50234157(CHEMBL4089227)
Affinity DataIC50: 0.631nMAssay Description:Inhibition of recombinant human His6-tagged PI3K p110delta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2019
Entry Details Article
PubMed
LigandPNGBDBM50234157(CHEMBL4089227)
Affinity DataIC50: 20nMAssay Description:Inhibition of PI3Kdelta-mediated AKT phosphorylation at ser473 residue in human JeKo1 cells preincubated for 60 mins followed by anti-IgM stimulation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2019
Entry Details Article
PubMed
LigandPNGBDBM50234157(CHEMBL4089227)
Affinity DataIC50: 79nMAssay Description:Inhibition of recombinant human His6-tagged PI3K p110alpha/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2019
Entry Details Article
PubMed
LigandPNGBDBM50234157(CHEMBL4089227)
Affinity DataIC50: 251nMAssay Description:Inhibition of recombinant human His6-tagged PI3Kgamma (144 to 1102 residues) using DiC8-PIP2 as substrate preincubated for 15 mins followed by substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2019
Entry Details Article
PubMed
LigandPNGBDBM50234157(CHEMBL4089227)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant human His6-tagged PI3K p110beta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate additi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2019
Entry Details Article
PubMed
LigandPNGBDBM50234157(CHEMBL4089227)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of PI3Kgamma-mediated AKT phosphorylation at ser473 in mouse RAW246 cells preincubated for 3 hrs followed by C5a stimulation measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2019
Entry Details Article
PubMed