BDBM50234808 CHEMBL4090007

SMILES CCOC(=O)c1c(\C(=C\N)C#N)c2ccc(Cl)c(Cl)c2n1C

InChI Key InChIKey=CXJCGSPAPOTTSF-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50234808   

TargetDual specificity protein kinase CLK1(Human)
Comenius University In Bratislava

Curated by ChEMBL
LigandPNGBDBM50234808(CHEMBL4090007)
Affinity DataIC50: 20nMAssay Description:Inhibition of human CLK1 (148 to 484 residues) expressed in Escherichia coli BL21(DE3) preincubated for 10 mins followed by AFRREWSPGKEAKK substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2019
Entry Details Article
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
Comenius University In Bratislava

Curated by ChEMBL
LigandPNGBDBM50234808(CHEMBL4090007)
Affinity DataIC50: 55nMAssay Description:Inhibition of human DYRK1A preincubated for 10 mins followed by YRASPSRPESPRPPA-amide substrate addition by pyruvate kinase and lactate dehydrogenase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2019
Entry Details Article
PubMed
TargetDual specificity protein kinase CLK3(Human)
Comenius University In Bratislava

Curated by ChEMBL
LigandPNGBDBM50234808(CHEMBL4090007)
Affinity DataIC50: 530nMAssay Description:Inhibition of human CLK3 (275 to 632 residues) expressed in Escherichia coli BL21(DE3) preincubated for 10 mins followed by substrate addition by pyr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2019
Entry Details Article
PubMed