BDBM50234944 CHEMBL4072538::US10239861, Example 60

SMILES CN1CCC[C@H](C1)NC2=C(C(=O)N(N=C2)C)Cl

InChI Key InChIKey=LEPPHANDICKARV-UHFFFAOYSA-N

Data  4 IC50

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50234944   

TargetBromodomain-containing protein 9(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50234944(CHEMBL4072538 | US10239861, Example 60)
Affinity DataIC50: 5.01E+4nMAssay Description:Displacement of GSK2833930A from human BRD9 incubated for 30 mins in dark by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2019
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT2B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50234944(CHEMBL4072538 | US10239861, Example 60)
Affinity DataIC50: 501nMAssay Description:Displacement of GSK3103956A from FLAG-6 His-Halo tagged human PCAF bromodomain (715 to 831 residues) incubated for 30 mins in dark by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHistone acetyltransferase KAT2B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50234944(CHEMBL4072538 | US10239861, Example 60)
Affinity DataIC50: 235nMAssay Description:His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetNucleosome-remodeling factor subunit BPTF(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50234944(CHEMBL4072538 | US10239861, Example 60)
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of HIS9-tagged BPTF (unknown origin) expressed in Escherichia coli BL21 (DE3) cells incubated for 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)