BDBM50234945 CHEMBL4061142::US10239861, Example 59

SMILES CN1CCC[C@@H](C1)Nc1cnn(C)c(=O)c1Cl

InChI Key InChIKey=LEPPHANDICKARV-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50234945   

TargetHistone acetyltransferase KAT2B(Human)
Genetech

US Patent
LigandPNGBDBM50234945(CHEMBL4061142 | US10239861, Example 59)
Affinity DataIC50: 51.2nMAssay Description:His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

TargetHistone acetyltransferase KAT2B(Human)
Genetech

US Patent
LigandPNGBDBM50234945(CHEMBL4061142 | US10239861, Example 59)
Affinity DataIC50: 6.31E+3nMAssay Description:Displacement of GSK3103956A from FLAG-6 His-Halo tagged human PCAF bromodomain (715 to 831 residues) incubated for 30 mins in dark by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2019
Entry Details Article
PubMed
TargetBromodomain-containing protein 9(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50234945(CHEMBL4061142 | US10239861, Example 59)
Affinity DataIC50: 5.01E+4nMAssay Description:Displacement of GSK2833930A from human BRD9 incubated for 30 mins in dark by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2019
Entry Details Article
PubMed