BDBM50235211 CHEMBL4093830

SMILES Cc1nc(ccc1S(C)(=O)=O)N1CCC2(C1)CCN(C[C@H](O)c1ccc3C(=O)OCc3c1C)CC2

InChI Key InChIKey=HRBREEFPWISDOT-UHFFFAOYSA-N

Data  3 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50235211   

TargetATP-sensitive inward rectifier potassium channel 1(Human)
Merck Sharp & Dohme

US Patent

LigandBDBM50235211(CHEMBL4093830)Copy SMILESCopy InChI

Affinity DataIC50: 75.7nMAssay Description:Assay Protocol: The ROMK channel functional thallium flux assay was performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells were ...More data for this Ligand-Target Pair

Target InfoKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
7/11/2019
Entry Details
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TargetATP-sensitive inward rectifier potassium channel 1(Human)
Merck Sharp & Dohme

US Patent

LigandBDBM50235211(CHEMBL4093830)Copy SMILESCopy InChI

Affinity DataIC50: 76nMAssay Description:Inhibition of human ROMK expressed in HEK293 cells after 30 mins by thallium flux assayMore data for this Ligand-Target Pair

Target InfoKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
6/28/2019
Entry Details Article
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TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck

Curated by ChEMBL

LigandBDBM50235211(CHEMBL4093830)Copy SMILESCopy InChI

Affinity DataIC50: 7.90E+3nMAssay Description:Displacement of [35S]MK499 from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
6/28/2019
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL