BDBM50236003 CHEMBL4096234

SMILES c1ccc(cc1)CN2CCc3c(c4nncn4c(c3C#N)NCc5ccco5)C2

InChI Key InChIKey=QBTUKQKTXYTWPD-UHFFFAOYSA-N

Data  8 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50236003   

TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50236003(CHEMBL4096234)
Affinity DataIC50: 4.03E+3nMAssay Description:Inhibition of recombinant N-terminal GST-tagged EED (76 to 441 residues) (unknown origin) expressed in Escherichia coli BL21-CodonPlus(DE3)-RIL asses...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50236003(CHEMBL4096234)
Affinity DataIC50: 620nMAssay Description:Inhibition of recombinant N-terminal GST-tagged EED (76 to 441 residues) (unknown origin) expressed in Escherichia coli BL21-CodonPlus(DE3)-RIL incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50236003(CHEMBL4096234)
Affinity DataIC50: 4.03E+3nMAssay Description:Inhibition of EED in human G401 cells assessed as reduction in global H3K27me3 level after 48 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50236003(CHEMBL4096234)
Affinity DataIC50: 620nMAssay Description:Inhibition of biotinylated H3K27Me3 peptide (19 to 33 aa) binding to EED (1 to 441 residues) (unknown origin) expressed in Escherichia coli BL21-Codo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50236003(CHEMBL4096234)
Affinity DataIC50: 3.28E+3nMAssay Description:Inhibition of EED in human G-401 cells assessed as reduction of global H3K27Me3 level by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50236003(CHEMBL4096234)
Affinity DataIC50: 4.03E+3nMAssay Description:Inhibition of EED (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50236003(CHEMBL4096234)
Affinity DataIC50: 320nMAssay Description:Binding affinity to his tagged EED (1 to 441 residues) (unknown origin) incubated for 20 mins in presence of biotinylated H3K27me3 peptide (19 to 33 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50236003(CHEMBL4096234)
Affinity DataIC50: 4.03E+3nMAssay Description:Inhibition of EED (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMedPDB3D3D Structure (crystal)