BDBM50236226 CHEMBL4087412::US11186582, Example 378::US11419874, Example 25

SMILES Cc1cc(C2CCCN(C2)C(=O)c2ccc3CCOc3c2)n2ncnc2n1

InChI Key InChIKey=VOQJMNVKRKGOBN-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50236226   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Oslo University Hospital

US Patent
LigandPNGBDBM50236226(CHEMBL4087412 | US11186582, Example 378 | US114198...)
Affinity DataIC50: 3nMAssay Description:Isolated cardiomyocytes were washed twice in PBS at room temperature, transferred to 4% paraformaldehyde (PFA) and gently shaken for 30 min, then was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
US Patent

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Oslo University Hospital

US Patent
LigandPNGBDBM50236226(CHEMBL4087412 | US11186582, Example 378 | US114198...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human full length GST-tagged PDE2a using FAM-labeled cAMP as substrate preincubated for 5 mins followed by substrate addition measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2019
Entry Details Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Oslo University Hospital

US Patent
LigandPNGBDBM50236226(CHEMBL4087412 | US11186582, Example 378 | US114198...)
Affinity DataIC50: 100nMAssay Description:An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2022
Entry Details
US Patent