BDBM50236251 7-[(1E)-1-(methoxyimino)ethyl]-19-methyl-3-(2-methylpropyl)-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-14-one::CHEMBL258015

SMILES CO\N=C(/C)c1ccc2n(CC(C)C)c3c4CCc5nn(C)cc5-c4c4C(=O)NCc4c3c2c1

InChI Key InChIKey=UGGGUUOMJJSLOR-UHFFFAOYSA-N

Data  8 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50236251   

LigandPNGBDBM50236251(7-[(1E)-1-(methoxyimino)ethyl]-19-methyl-3-(2-meth...)
Affinity DataIC50: 4nMAssay Description:Inhibition of VEGF-stimulated VEGFR2 autophosphorylation in HUVEC cells at 50 nM relative to controlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
LigandPNGBDBM50236251(7-[(1E)-1-(methoxyimino)ethyl]-19-methyl-3-(2-meth...)
Affinity DataIC50: 7nMAssay Description:Inhibition of human recombinant VEGFR2 by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
LigandPNGBDBM50236251(7-[(1E)-1-(methoxyimino)ethyl]-19-methyl-3-(2-meth...)
Affinity DataIC50: 8nMAssay Description:Inhibition of VEGFR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
LigandPNGBDBM50236251(7-[(1E)-1-(methoxyimino)ethyl]-19-methyl-3-(2-meth...)
Affinity DataIC50: 10nMAssay Description:Inhibition of VEGFR3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50236251(7-[(1E)-1-(methoxyimino)ethyl]-19-methyl-3-(2-meth...)
Affinity DataIC50: 30nMAssay Description:Inhibition of human recombinant TIE2 by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50236251(7-[(1E)-1-(methoxyimino)ethyl]-19-methyl-3-(2-meth...)
Affinity DataIC50: 43nMAssay Description:Inhibition of c-srcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50236251(7-[(1E)-1-(methoxyimino)ethyl]-19-methyl-3-(2-meth...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of IRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50236251(7-[(1E)-1-(methoxyimino)ethyl]-19-methyl-3-(2-meth...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed