BDBM50236333 CHEMBL4092052

SMILES NC(=O)c1cccc(c1)-c1ccc(OC(=O)NCCCCN2CCN(CC2)c2cccc(Cl)c2Cl)cc1

InChI Key InChIKey=RMHUUXBXQCLMOK-UHFFFAOYSA-N

Data  1 IC50  5 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50236333   

TargetFatty-acid amide hydrolase 1(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50236333(CHEMBL4092052)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of human FAAH1 expressed in HEK293 cell membrane-enriched lysate using AMC arachidonyl amide as substrate preincubated for 50 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2019
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50236333(CHEMBL4092052)
Affinity DataEC50:  1nMAssay Description:Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2019
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50236333(CHEMBL4092052)
Affinity DataEC50:  1nMAssay Description:Partial agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of cAMP accumulation by flourescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50236333(CHEMBL4092052)
Affinity DataEC50:  13nMAssay Description:Agonist activity at human dopamine D2 receptor-short expressed in CHO-K1 cells assessed as reduction in adenylyl cyclase activator NKH 477 induced cA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2019
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50236333(CHEMBL4092052)
Affinity DataEC50:  14nMAssay Description:Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2019
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50236333(CHEMBL4092052)
Affinity DataEC50:  14nMAssay Description:Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2019
Entry Details Article
PubMed