BDBM50236675 CHEMBL4102106

SMILES Cc1cc(COc2ccc(cc2)S(=O)(=O)N2CCN(C(C2)C(=O)NO)C(=O)C(C)(C)C)c2CCCCc2n1

InChI Key InChIKey=XPKONFJMLMUKJB-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50236675   

LigandPNGBDBM50236675(CHEMBL4102106)
Affinity DataIC50: 12nMAssay Description:Inhibition of recombinant human TACE catalytic domain using Mca-Pro-Leu-Ala-Gln-Ala-Val-Dpa-Arg-Ser-Ser-Ser-Arg-NH2 as substrate after 2 hrs by fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2019
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50236675(CHEMBL4102106)
Affinity DataIC50: 930nMAssay Description:Inhibition of MMP12 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2019
Entry Details Article
PubMed
LigandPNGBDBM50236675(CHEMBL4102106)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of TACE in NHEK assessed as reduction in LPS/TPA-stimulated TNFalpha production preincubated for 1 hr followed by LPS/TPA stimulation for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2019
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50236675(CHEMBL4102106)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MMP9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2019
Entry Details Article
PubMed
LigandPNGBDBM50236675(CHEMBL4102106)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ADAM9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2019
Entry Details Article
PubMed
LigandPNGBDBM50236675(CHEMBL4102106)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ADAM10 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2019
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50236675(CHEMBL4102106)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MMP3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2019
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50236675(CHEMBL4102106)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human MMP1 catalytic domain using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate after 10 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2019
Entry Details Article
PubMed