BDBM50237516 CHEMBL4080712::US10836758, Example 18

SMILES N[C@H]1CC[C@H](CCNc2cc(F)c(cc2Cl)S(=O)(=O)Nc2nccs2)CC1

InChI Key InChIKey=GPWHPAPWDUMHKB-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50237516   

TargetSodium channel protein type 9 subunit alpha(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50237516(CHEMBL4080712 | US10836758, Example 18)
Affinity DataIC50: 14nMAssay Description:Inhibition of recombinant human Nav1.7 expressed in HEK293 cells assessed as reduction in peak inward current at -60 mV holding potential measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2019
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50237516(CHEMBL4080712 | US10836758, Example 18)
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of human CYP3A4 assessed as inhibition of dealkylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2019
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50237516(CHEMBL4080712 | US10836758, Example 18)
Affinity DataIC50: 14nMAssay Description:hNaV1.7 binding affinities were determined with a filtration binding assay using purified membranes from HEK293 cells stably expressing hNaV1.7. HEK2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2021
Entry Details
Go to US Patent