BDBM50237519 CHEMBL4097237::US10836758, Example 21

SMILES N[C@H]1CC[C@H](CNc2cc(F)c(cc2Cl)S(=O)(=O)Nc2nccs2)CC1

InChI Key InChIKey=UDLDRWWTJMCAEM-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50237519   

TargetSodium channel protein type 9 subunit alpha(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50237519(CHEMBL4097237 | US10836758, Example 21)
Affinity DataIC50: 398nMAssay Description:Inhibition of recombinant human Nav1.7 expressed in HEK293 cells assessed as reduction in peak inward current at -60 mV holding potential measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2019
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50237519(CHEMBL4097237 | US10836758, Example 21)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant human Nav1.5 expressed in HEK293 cells assessed as reduction in peak inward current at -50 mV holding potential measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2019
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50237519(CHEMBL4097237 | US10836758, Example 21)
Affinity DataIC50: 398nMAssay Description:hNaV1.7 binding affinities were determined with a filtration binding assay using purified membranes from HEK293 cells stably expressing hNaV1.7. HEK2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2021
Entry Details
Go to US Patent