BDBM50238245 CHEMBL4070311

SMILES [H][C@]12C[C@@]1([H])N([C@@H](C2)C(=O)Nc1cccc(c1F)C(F)(F)F)C(=O)Nc1cn(C(N)=O)c2ccccc12

InChI Key InChIKey=TUEKTSQDUDFOLZ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50238245   

TargetComplement factor D(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50238245(CHEMBL4070311)
Affinity DataIC50: 587nMAssay Description:Inhibition of complement factor D in human whole blood assessed as decrease in zymosan-induced AP activation mediated soluble MAC complex formation p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2019
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50238245(CHEMBL4070311)
Affinity DataIC50: 150nMAssay Description:Inhibition of CYP2C9 (unknown origin) using diclofenac as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2019
Entry Details Article
PubMed
TargetComplement factor D(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50238245(CHEMBL4070311)
Affinity DataIC50: 23nMAssay Description:Inhibition of recombinant human complement factor D catalytic domain using Z-Lys-thiobenzylester as substrate preincubated for 1 hr followed by subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2019
Entry Details Article
PubMed