BDBM50238248 CHEMBL4094108

SMILES [H][C@]12C[C@@]1([H])N([C@@H](C2)C(=O)Nc1cccc(OC(F)(F)F)c1F)C(=O)Nc1cn(C(N)=O)c2ccccc12

InChI Key InChIKey=ABCCEOMCSDAAKH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50238248   

TargetCytochrome P450 2C9(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50238248(CHEMBL4094108)
Affinity DataIC50: 250nMAssay Description:Inhibition of CYP2C9 (unknown origin) using diclofenac as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2019
Entry Details Article
PubMed
TargetComplement factor D(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50238248(CHEMBL4094108)
Affinity DataIC50: 12nMAssay Description:Inhibition of recombinant human complement factor D catalytic domain using Z-Lys-thiobenzylester as substrate preincubated for 1 hr followed by subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2019
Entry Details Article
PubMed
TargetComplement factor D(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50238248(CHEMBL4094108)
Affinity DataIC50: 250nMAssay Description:Inhibition of complement factor D in human whole blood assessed as decrease in zymosan-induced AP activation mediated soluble MAC complex formation p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2019
Entry Details Article
PubMed