BDBM50239310 CHEMBL3770841

SMILES OC(=O)c1ccc(Nc2nc(nc3ccccc23)-c2ccncc2)cc1

InChI Key InChIKey=QYJWXOYAPRIBLA-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50239310   

TargetATP-dependent translocase ABCB1(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50239310(CHEMBL3770841)
Affinity DataIC50: 3.67E+3nMAssay Description:Inhibition of ABCB1 in human A2780adr cells assessed as reduction in calcein AM levels preincubated for 30 mins followed by calcein AM addition measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2019
Entry Details Article
PubMed
LigandPNGBDBM50239310(CHEMBL3770841)
Affinity DataIC50: 9.64E+3nMAssay Description:Inhibition of recombinant human GFP-fused ABCG2 expressed in MDCK2 cells assessed as reduction in Hoechst 33342 efflux preincubated for 30 mins follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2019
Entry Details Article
PubMed
TargetStructural capsid protein(Human immunodeficiency virus type 1)
Charles University

Curated by ChEMBL
LigandPNGBDBM50239310(CHEMBL3770841)
Affinity DataIC50: 1.00E+5nMAssay Description:Binding affinity to recombinant N-terminal GST-tagged HIV1 NL4-3 capsid C-terminal domain (146 to 231 residues) incubated for 2 hrs by alphascreen as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed