BDBM50239552 CHEMBL4070433

SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2scc(C)n2c(=O)c1-c1cccc(CN2CCC(CC2)N(C)C)c1

InChI Key InChIKey=JSFPZUBRLYUNHU-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50239552   

LigandPNGBDBM50239552(CHEMBL4070433)
Affinity DataIC50: 0.501nMAssay Description:Inhibition of recombinant human His6-tagged PI3K p110delta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2019
Entry Details Article
PubMed
LigandPNGBDBM50239552(CHEMBL4070433)
Affinity DataIC50: 10nMAssay Description:Inhibition of PI3Kdelta in human JeKo1 cells assessed as reduction in Akt phosphorylation at Ser473 residue preincubated for 60 mins followed by Anti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2019
Entry Details Article
PubMed
LigandPNGBDBM50239552(CHEMBL4070433)
Affinity DataIC50: 63nMAssay Description:Inhibition of recombinant human His6-tagged PI3K p110beta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate additi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2019
Entry Details Article
PubMed