BDBM50239911 CHEMBL4094084::US10287286, Example 26

SMILES Cc1cc(cc(C)c1-c1cccc2ncnn12)C#N

InChI Key InChIKey=RKMWDUWATTXHKI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50239911   

TargetProlyl hydroxylase EGLN2(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM50239911(CHEMBL4094084 | US10287286, Example 26)
Affinity DataIC50: 197nMAssay Description:The IC50 values for the PHD1 enzyme (residues 1-407) were determined by mixing increasing amounts of a compound of the invention with a fixed amount ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/29/2020
Entry Details
Go to US Patent

TargetProlyl hydroxylase EGLN2(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM50239911(CHEMBL4094084 | US10287286, Example 26)
Affinity DataIC50: 200nMAssay Description:Inhibition of full length HIF-PHD1 (unknown origin) expressed in baculovirus infected sf9 cells using DLDLEMLAPYIPMDDDFQL/2-Oxoglutarate as substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2019
Entry Details Article
PubMed