BDBM50239912 CHEMBL4064841::US10287286, Example 34

SMILES Cc1cc(cc(F)c1-c1cccc2ncnn12)C#N

InChI Key InChIKey=GRRJHIVATRJJEV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50239912   

TargetProlyl hydroxylase EGLN2(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM50239912(CHEMBL4064841 | US10287286, Example 34)
Affinity DataIC50: 223nMAssay Description:The IC50 values for the PHD1 enzyme (residues 1-407) were determined by mixing increasing amounts of a compound of the invention with a fixed amount ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/29/2020
Entry Details
Go to US Patent

TargetProlyl hydroxylase EGLN2(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM50239912(CHEMBL4064841 | US10287286, Example 34)
Affinity DataIC50: 220nMAssay Description:Inhibition of full length HIF-PHD1 (unknown origin) expressed in baculovirus infected sf9 cells using DLDLEMLAPYIPMDDDFQL/2-Oxoglutarate as substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2019
Entry Details Article
PubMed