BDBM50239928 CHEMBL4094977::US10287286, Example 23

SMILES Fc1c(F)c(ccc1C#N)-c1cccc2ncnn12

InChI Key InChIKey=PAQNXWWTZCDJGC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50239928   

TargetProlyl hydroxylase EGLN2(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM50239928(CHEMBL4094977 | US10287286, Example 23)
Affinity DataIC50: 67nMAssay Description:The IC50 values for the PHD1 enzyme (residues 1-407) were determined by mixing increasing amounts of a compound of the invention with a fixed amount ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/29/2020
Entry Details
Go to US Patent

TargetProlyl hydroxylase EGLN2(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM50239928(CHEMBL4094977 | US10287286, Example 23)
Affinity DataIC50: 67nMAssay Description:Inhibition of full length HIF-PHD1 (unknown origin) expressed in baculovirus infected sf9 cells using DLDLEMLAPYIPMDDDFQL/2-Oxoglutarate as substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2019
Entry Details Article
PubMed