BDBM50239930 CHEMBL4085560::US10287286, Example 227

SMILES Nc1ccc2ncnn2c1-c1ccc(cc1)C#N

InChI Key InChIKey=JQSPRHORZWCDKZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50239930   

TargetProlyl hydroxylase EGLN2(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50239930(CHEMBL4085560 | US10287286, Example 227)
Affinity DataIC50: 770nMAssay Description:Inhibition of full length HIF-PHD1 (unknown origin) expressed in baculovirus infected sf9 cells using DLDLEMLAPYIPMDDDFQL/2-Oxoglutarate as substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2019
Entry Details Article
PubMed
TargetProlyl hydroxylase EGLN2(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50239930(CHEMBL4085560 | US10287286, Example 227)
Affinity DataIC50: 774nMAssay Description:The IC50 values for the PHD1 enzyme (residues 1-407) were determined by mixing increasing amounts of a compound of the invention with a fixed amount ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/29/2020
Entry Details
US Patent