BDBM50239947 CHEMBL4089730::US20230303494, Compound BMS202::US20240043392, Compound BMS-202::US20240327387, Compound BMS202::US9872852, Example 202
SMILES COc1nc(OCc2cccc(c2C)-c2ccccc2)ccc1CNCCNC(C)=O
InChI Key InChIKey=JEDPSOYOYVELLZ-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 58 hits for monomerid = 50239947
Affinity DataIC50: 5.51E+4nMAssay Description:Inhibition of PD-1/PD-L1 interaction (unknown origin) incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Inhibition of Ig-tagged PD-1 (unknown origin)/His-tagged PD-L1 (unknown origin) protein-protein interaction preincubated with PD-L1 for 15 mins follo...More data for this Ligand-Target Pair
Affinity DataIC50: 101nMAssay Description:Inhibition of PD-1 binding to human PD-L1 by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Inhibition of PD-1 (unknown origin)/PD-L1 (unknown origin) interaction by HTRF binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 96nMAssay Description:Inhibition of PD-1/PD-L1 (unknown origin) interaction incubated for 15 mins by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 227nMAssay Description:Inhibition of human PD-1/PD-L1 interaction overexpressed in human HEK293T cells by flow cytometry analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Inhibition of PD-1/PD-L1 interaction (unknown origin) incubated for 24 hrs by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Inhibition of human PD-1/PDL1 protein-protein interaction by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Inhibition of human PD-1/PDL1 protein-protein interactionMore data for this Ligand-Target Pair
TargetProgrammed cell death 1 ligand 1(Human)
Acharya & Bm Reddy College of Pharmacy
Curated by ChEMBL
Acharya & Bm Reddy College of Pharmacy
Curated by ChEMBL
Affinity DataKd: 135nMAssay Description:Binding affinity to human PDL1 assessed as dissociation constant by MST methodMore data for this Ligand-Target Pair
TargetProgrammed cell death 1 ligand 1(Human)
Acharya & Bm Reddy College of Pharmacy
Curated by ChEMBL
Acharya & Bm Reddy College of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 18nMAssay Description:Inhibition of human PD-L1 (18 to 134 residues) expressed in Escherichia coli BL21 (DE3) incubated for 1 hr by spectrophometric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 54nMAssay Description:Inhibition of PD-1/PD-L1 (unknown origin) protein-protein interaction by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Inhibition of recombinant human PD-1 (33 to 150 residues)/recombinant human PD-L1 (18 to 134 residues) expressed Escherichia coli BL21 (DE3) cells by...More data for this Ligand-Target Pair
Affinity DataIC50: 31nMAssay Description:Inhibition of PD-1/PD-L1 (unknown origin) protein-protein interaction incubated for 15 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:As further confirmation of the results of the NMR assay and to classify the compounds of the invention based on their in vitro ability to inhibit PD-...More data for this Ligand-Target Pair
Affinity DataIC50: 87nMAssay Description:Inhibition of PD-1/PD-L1 interaction (unknown origin) incubated for 60 min by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Inhibition of europium-labeled PD-1/biotinylated PD-L1 interaction (unknown origin) preincubated for 15 mins with PD-L1 followed by PD-1 addition and...More data for this Ligand-Target Pair
TargetProgrammed cell death 1 ligand 1(Human)
Acharya & Bm Reddy College of Pharmacy
Curated by ChEMBL
Acharya & Bm Reddy College of Pharmacy
Curated by ChEMBL
TargetProgrammed cell death 1 ligand 1(Human)
Acharya & Bm Reddy College of Pharmacy
Curated by ChEMBL
Acharya & Bm Reddy College of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 17nMAssay Description:Inhibition of PD1/PD-L1 (unknown origin) protein-protein interaction measured after 135 mins by TR-FRET assay relative to controlMore data for this Ligand-Target Pair
TargetProgrammed cell death 1 ligand 1(Human)
Acharya & Bm Reddy College of Pharmacy
Curated by ChEMBL
Acharya & Bm Reddy College of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 18nMAssay Description:Binding affinity to His-tagged PD-L1 (unknown origin) assessed as reduction in PD-L1/PD1-Ig interaction preincubated with PD-L1 for 15 mins followed ...More data for this Ligand-Target Pair
TargetProgrammed cell death 1 ligand 1(Human)
Acharya & Bm Reddy College of Pharmacy
Curated by ChEMBL
Acharya & Bm Reddy College of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 18nMAssay Description:All binding studies were performed in an HTRF assay buffer consisting of dPBS supplemented with 0.1% (withv) bovine serum albumin and 0.05% (v/v) Twe...More data for this Ligand-Target Pair
TargetProgrammed cell death 1 ligand 1(Human)
Acharya & Bm Reddy College of Pharmacy
Curated by ChEMBL
Acharya & Bm Reddy College of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 18nMAssay Description:Inhibition of PD-L1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataEC50: 2.76E+3nMAssay Description:Inhibition of PD1/PDL1 interaction in human Jurkat cells co-cultured with human U2OS cells expressing PDL1 assessed as reduction in SHP1 recruitment ...More data for this Ligand-Target Pair
Affinity DataIC50: 96nMAssay Description:Inhibition of human Fc-tagged PD1 N-terminal domain (Leu25 to Gln167 residues) expressed in HEK293 cells/human His-tagged PDL1 (Phe19 to Arg238 resid...More data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of human PD1 stably expressed in human Jurkat T cells co-expressing NFAT-induced luciferase/human PDL1 stably expressed in CHOK1 cells co-...More data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Inhibition of PD1/PDL1 interaction (unknown origin) after 15 mins by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Inhibition of Ig-tagged human PD1/His-tagged human PDL1 interaction incubated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 61nMAssay Description:Inhibition of human PD1/PDL1 protein-protein interaction by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 191nMAssay Description:Inhibition of PD1 (unknown origin)/PDL1 (unknown origin) protein-protein interaction by HTRF assayMore data for this Ligand-Target Pair
TargetProgrammed cell death 1 ligand 1(Human)
Acharya & Bm Reddy College of Pharmacy
Curated by ChEMBL
Acharya & Bm Reddy College of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 18nMAssay Description:Binding affinity to PDL1 (unknown origin) assessed as reduction in PDL1/PD1 protein-protein interaction preincubated for 15 mins followed by PD1 addi...More data for this Ligand-Target Pair
Affinity DataIC50: 61nMAssay Description:Inhibition of PD1/PDL1 (unknown origin) protein-protein interaction measured after 15 mins by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Inhibition of human PD-1/PDL1 by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 61nMAssay Description:Inhibition of PD-1/PDL1 (unknown origin) measured after 2 hrs by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 55nMAssay Description:A negative control, a positive control and drug administration groups were set up, with two duplicate wells in each group. For the positive control g...More data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Inhibition of PD1/PD-L1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of human PD-1/PD-L1 interaction in human Jurkat cells expressing PD-1/NFAT/Luc cocultured with CHO-K1 cells expressing PD-L1/aAPC assessed...More data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Inhibition of human PD1/PDL1 protein-protein interaction expressed in Escherichia coli BL21 (DE3) by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of PD-1/PD-L1 interaction (unknown origin) preincubated with PD-L1 for 15 mins followed by PD-1 addition measured after 90 mins by TR-FRET...More data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Inhibition of PD-1/PDL-1 (unknown origin) bindingMore data for this Ligand-Target Pair