BDBM50240847 2,5-Bis-[1-phenyl-meth-(E)-ylidene]-cyclopentanone::2,5-dibenzylidenecyclopentanone::CHEMBL151734

SMILES O=C1\C(CC\C1=C/c1ccccc1)=C\c1ccccc1

InChI Key InChIKey=CVTOCKKPVXJIJK-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50240847   

TargetCytochrome P450 1A2(Human)
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM50240847(2,5-Bis-[1-phenyl-meth-(E)-ylidene]-cyclopentanone...)
Affinity DataIC50: 3.66E+4nMAssay Description:Inhibition of human recombinant CYP1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM50240847(2,5-Bis-[1-phenyl-meth-(E)-ylidene]-cyclopentanone...)
Affinity DataIC50: 3.66E+4nMAssay Description:Inhibition of human recombinant CYP1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGlutathione reductase, mitochondrial(Human)
Universidade Federal De Minas Gerais

Curated by ChEMBL
LigandPNGBDBM50240847(2,5-Bis-[1-phenyl-meth-(E)-ylidene]-cyclopentanone...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant glutathione reductase using glutathione as substrate preincubated for 30 mins by colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Universidade Federal De Minas Gerais

Curated by ChEMBL
LigandPNGBDBM50240847(2,5-Bis-[1-phenyl-meth-(E)-ylidene]-cyclopentanone...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of Trypanosoma cruzi trypanothione reductase expressed in Escherichia coli BL21(DE3) assessed as reduction of oxidized trypanothione prein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed