BDBM50241843 CHEMBL4102250::US10899756, Compound N

SMILES CCN1Cc2nc3ccc(Cl)cc3c(NCc3ccc(OC)c(Cl)c3)c2C1=O

InChI Key InChIKey=PSLIYZXVRBZMDB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50241843   

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Columbia University

Curated by ChEMBL
LigandPNGBDBM50241843(CHEMBL4102250 | US10899756, Compound N)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of human recombinant PDE5A1 using FAM-labelled cGMP as substrate after 60 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2019
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Columbia University

Curated by ChEMBL
LigandPNGBDBM50241843(CHEMBL4102250 | US10899756, Compound N)
Affinity DataIC50: 1.70nMAssay Description:A series of dilutions of the test compounds were prepared with 10% DMSO in assay buffer and 5 μl of the dilution was added to a 50 μl react...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2021
Entry Details
Go to US Patent