BDBM50241866 CHEMBL4063709

SMILES Cn1cc(cn1)-c1ccncc1\C=C\C(=O)Nc1ccc(CN2CCOCC2)cc1

InChI Key InChIKey=RONMYLLIYUXIFC-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50241866   

TargetCyclin-C/Cyclin-dependent kinase 19(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50241866(CHEMBL4063709)
Affinity DataIC50: 15nMAssay Description:Inhibition of kinase tracer 236 binding to GST-tagged CDK19/CycC (unknown origin) after 60 min by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2019
Entry Details Article
PubMed
TargetCyclin-C(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50241866(CHEMBL4063709)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of kinase tracer 236 binding to full length N terminal GST-tagged human CDK8 (1 to 464 end residues) /CycC ( 1 to 283 end residues) expres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2019
Entry Details Article
PubMed
TargetCyclin-dependent kinase 8(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50241866(CHEMBL4063709)
Affinity DataEC50:  13nMAssay Description:Inhibition of CDK8 in human SW480 cells assessed as reduction in IFN-gamma induced STAT1 phosphorylation at Ser727 residues preincubated for 2 hrs fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2019
Entry Details Article
PubMed