BDBM50242154 CHEMBL4099788::US10626113, Compound A::US10899756, Compound A

SMILES COc1ccc(CNc2c3CN(C)CCc3nc3ccc(Br)cc23)cc1Cl

InChI Key InChIKey=UMTRDSJALRKNQI-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50242154   

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Columbia University

Curated by ChEMBL
LigandPNGBDBM50242154(CHEMBL4099788 | US10899756, Compound A | US1062611...)
Affinity DataIC50: 22nMAssay Description:Inhibition of human recombinant PDE5A1 using FAM-labelled cGMP as substrate after 60 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2019
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Columbia University

Curated by ChEMBL
LigandPNGBDBM50242154(CHEMBL4099788 | US10899756, Compound A | US1062611...)
Affinity DataIC50: 21.6nMAssay Description:A series of dilutions of the test compounds were prepared with 10% DMSO in assay buffer and 5 μl of the dilution was added to a 50 μl react...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2021
Entry Details
Go to US Patent

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Columbia University

Curated by ChEMBL
LigandPNGBDBM50242154(CHEMBL4099788 | US10899756, Compound A | US1062611...)
Affinity DataIC50: 21.6nMAssay Description:Materials and Methods: PDE5 inhibition was assayed at BPS Bioscience (San Diego, Calif.) using BPS PDE assay kits (BPS Catalog number 60300, enzyme l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2023
Entry Details
Go to US Patent