BDBM50243761 4-(1H-Indol-3-yl)-3-(3,4,5-trimethoxyphenyl)-1,5-dihydro-2H-pyrrole-2-one::CHEMBL529663

SMILES COc1cc(cc(OC)c1OC)C1=C(CNC1=O)c1c[nH]c2ccccc12

InChI Key InChIKey=YTFRDKYCZHOSMM-UHFFFAOYSA-N

Data  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50243761   

TargetVascular endothelial growth factor receptor 2(Human)
Eberhard-Karls University

Curated by ChEMBL
LigandPNGBDBM50243761(4-(1H-Indol-3-yl)-3-(3,4,5-trimethoxyphenyl)-1,5-d...)
Affinity DataIC50: 31nMAssay Description:Inhibition of human recombinant VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 3(Human)
Eberhard-Karls University

Curated by ChEMBL
LigandPNGBDBM50243761(4-(1H-Indol-3-yl)-3-(3,4,5-trimethoxyphenyl)-1,5-d...)
Affinity DataIC50: 37nMAssay Description:Inhibition of human recombinant VEGFR3More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Eberhard-Karls University

Curated by ChEMBL
LigandPNGBDBM50243761(4-(1H-Indol-3-yl)-3-(3,4,5-trimethoxyphenyl)-1,5-d...)
Affinity DataIC50: 5.20E+3nMAssay Description:Inhibition of human recombinant TIE2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Eberhard-Karls University

Curated by ChEMBL
LigandPNGBDBM50243761(4-(1H-Indol-3-yl)-3-(3,4,5-trimethoxyphenyl)-1,5-d...)
Affinity DataIC50: 6.10E+3nMAssay Description:Inhibition of human recombinant FLT3More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetFocal adhesion kinase 1(Human)
Eberhard-Karls University

Curated by ChEMBL
LigandPNGBDBM50243761(4-(1H-Indol-3-yl)-3-(3,4,5-trimethoxyphenyl)-1,5-d...)
Affinity DataIC50: 9.50E+3nMAssay Description:Inhibition of human recombinant FAKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK4(Human)
Eberhard-Karls University

Curated by ChEMBL
LigandPNGBDBM50243761(4-(1H-Indol-3-yl)-3-(3,4,5-trimethoxyphenyl)-1,5-d...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant SAKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Eberhard-Karls University

Curated by ChEMBL
LigandPNGBDBM50243761(4-(1H-Indol-3-yl)-3-(3,4,5-trimethoxyphenyl)-1,5-d...)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of human recombinant PDGFRbetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Eberhard-Karls University

Curated by ChEMBL
LigandPNGBDBM50243761(4-(1H-Indol-3-yl)-3-(3,4,5-trimethoxyphenyl)-1,5-d...)
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of human recombinant SRCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Eberhard-Karls University

Curated by ChEMBL
LigandPNGBDBM50243761(4-(1H-Indol-3-yl)-3-(3,4,5-trimethoxyphenyl)-1,5-d...)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of human recombinant Aurora AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Eberhard-Karls University

Curated by ChEMBL
LigandPNGBDBM50243761(4-(1H-Indol-3-yl)-3-(3,4,5-trimethoxyphenyl)-1,5-d...)
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of human recombinant IGF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Eberhard-Karls University

Curated by ChEMBL
LigandPNGBDBM50243761(4-(1H-Indol-3-yl)-3-(3,4,5-trimethoxyphenyl)-1,5-d...)
Affinity DataIC50: 2.30E+4nMAssay Description:Inhibition of human recombinant EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 8(Human)
Eberhard-Karls University

Curated by ChEMBL
LigandPNGBDBM50243761(4-(1H-Indol-3-yl)-3-(3,4,5-trimethoxyphenyl)-1,5-d...)
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibition of human recombinant COTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Eberhard-Karls University

Curated by ChEMBL
LigandPNGBDBM50243761(4-(1H-Indol-3-yl)-3-(3,4,5-trimethoxyphenyl)-1,5-d...)
Affinity DataIC50: 4.30E+4nMAssay Description:Inhibition of human recombinant INS-RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Eberhard-Karls University

Curated by ChEMBL
LigandPNGBDBM50243761(4-(1H-Indol-3-yl)-3-(3,4,5-trimethoxyphenyl)-1,5-d...)
Affinity DataIC50: 4.60E+4nMAssay Description:Inhibition of human recombinant Aurora BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed