BDBM50244644 CHEMBL508870::rac-(E)-(4-{[4-(Dimethylamino)phenyl]methylene}-2-(hydroxymethyl)-5-oxo-2-2,3-dihydrofuryl)methyl 4-Methoxybenzoate::rac-(E/Z)-(4-(4-(dimethylamino)benzylidene)-2-(hydroxymethyl)-5-oxo-tetrahydrofuran-2-yl)methyl 4-methoxybenzoate

SMILES COc1ccc(cc1)C(=O)OCC1(CO)C\C(=C/c2ccc(cc2)N(C)C)C(=O)O1

InChI Key InChIKey=OFLLVGNLDKSIDQ-UHFFFAOYSA-N

Data  5 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50244644   

TargetRas guanyl-releasing protein 3(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50244644(rac-(E/Z)-(4-(4-(dimethylamino)benzylidene)-2-(hyd...)
Affinity DataKi:  7.5nMAssay Description:Displacement of [3H]PDBu from full length MBP-tagged human RasGRP3 expressed in Escherichia coli BL21 (DE3) after 5 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2020
Entry Details Article
PubMed
TargetProtein kinase C epsilon type(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50244644(rac-(E/Z)-(4-(4-(dimethylamino)benzylidene)-2-(hyd...)
Affinity DataKi:  18nMAssay Description:Displacement of [3H]PDBu from full length recombinant human PKCepsilon expressed in baculovirus expression system after 5 mins by scintillation count...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2020
Entry Details Article
PubMed
TargetProtein kinase C alpha type(Mouse)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50244644(rac-(E/Z)-(4-(4-(dimethylamino)benzylidene)-2-(hyd...)
Affinity DataKi:  102nMAssay Description:Displacement of [3H]PDBu form mouse PKCalpha by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProtein kinase C alpha type(Mouse)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50244644(rac-(E/Z)-(4-(4-(dimethylamino)benzylidene)-2-(hyd...)
Affinity DataKi:  103nMAssay Description:Displacement of [3H]PDBu form mouse PKCalpha by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProtein kinase C alpha type(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50244644(rac-(E/Z)-(4-(4-(dimethylamino)benzylidene)-2-(hyd...)
Affinity DataKi:  128nMAssay Description:Displacement of [3H]PDBu from full length recombinant human PKCalpha expressed in baculovirus expression system after 5 mins by scintillation countin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2020
Entry Details Article
PubMed