BDBM50245443 4-amino-6-(4-(benzyloxy)-3-chlorophenylamino)-N-(4-methoxyphenyl)pyrimidine-5-carboxamide::CHEMBL472383

SMILES COc1ccc(NC(=O)c2c(N)ncnc2Nc2ccc(OCc3ccccc3)c(Cl)c2)cc1

InChI Key InChIKey=QGRYIZRZEGPOEO-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50245443   

TargetAurora kinase A(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50245443(4-amino-6-(4-(benzyloxy)-3-chlorophenylamino)-N-(4...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Aurora AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50245443(4-amino-6-(4-(benzyloxy)-3-chlorophenylamino)-N-(4...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CDK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50245443(4-amino-6-(4-(benzyloxy)-3-chlorophenylamino)-N-(4...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of HER2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50245443(4-amino-6-(4-(benzyloxy)-3-chlorophenylamino)-N-(4...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed