BDBM50245517 CHEMBL4086343

SMILES Nc1ncnn2c(cc(-c3ccnn3CC(F)(F)F)c12)-c1cccc(c1)N1CCOCC1=O

InChI Key InChIKey=IMDGJJWMDCENIG-UHFFFAOYSA-N

Data  6 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50245517   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Bristol-Myers Squibb

Curated by ChEMBL

LigandBDBM50245517(CHEMBL4086343)Copy SMILESCopy InChI

Affinity DataIC50: 27nMAssay Description:Inhibition of PI3Kgamma (unknown origin) after 60 mins using fluorescein-labeled kinase tracer by HTRF assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
10/26/2019
Entry Details Article
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TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Bristol-Myers Squibb

Curated by ChEMBL

LigandBDBM50245517(CHEMBL4086343)Copy SMILESCopy InChI

Affinity DataIC50: 29nMAssay Description:Inhibition of PI3Kdelta (unknown origin) after 60 mins using fluorescein-labeled kinase tracer by HTRF assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
10/26/2019
Entry Details Article
Copy BDB DOIPubMed
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TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Bristol-Myers Squibb

Curated by ChEMBL

LigandBDBM50245517(CHEMBL4086343)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PI3Kdelta in ACD-treated human whole blood assessed as reduction in CD69 expression measured after 1 hrMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
10/26/2019
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Bristol-Myers Squibb

Curated by ChEMBL

LigandBDBM50245517(CHEMBL4086343)Copy SMILESCopy InChI

Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of PI3Kdelta in ACD-treated human whole blood assessed as reduction in IFNgammaX production measured after 1 hrMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
10/26/2019
Entry Details Article
Copy BDB DOIPubMed
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TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Bristol-Myers Squibb

Curated by ChEMBL

LigandBDBM50245517(CHEMBL4086343)Copy SMILESCopy InChI

Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of PI3Kalpha (unknown origin) after 60 mins using fluorescein-labeled kinase tracer by HTRF assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
10/26/2019
Entry Details Article
Copy BDB DOIPubMed
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TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Bristol-Myers Squibb

Curated by ChEMBL

LigandBDBM50245517(CHEMBL4086343)Copy SMILESCopy InChI

Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of PI3Kbeta (unknown origin) after 60 mins using fluorescein-labeled kinase tracer by HTRF assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
10/26/2019
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL