BDBM50245581 CHEMBL4092654

SMILES CC1(C)OCCN(C1=O)c1cc(ccc1C#N)-c1cc(Cl)c2c(N)ncnn12

InChI Key InChIKey=SAKNYPNGZWVPOL-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50245581   

LigandPNGBDBM50245581(CHEMBL4092654)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of PI3Kdelta (unknown origin) after 60 mins using fluorescein-labeled kinase tracer by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2019
Entry Details Article
PubMed
LigandPNGBDBM50245581(CHEMBL4092654)
Affinity DataIC50: 20nMAssay Description:Inhibition of PI3Kgamma (unknown origin) after 60 mins using fluorescein-labeled kinase tracer by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2019
Entry Details Article
PubMed
LigandPNGBDBM50245581(CHEMBL4092654)
Affinity DataIC50: 54nMAssay Description:Inhibition of PI3Kalpha (unknown origin) after 60 mins using fluorescein-labeled kinase tracer by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2019
Entry Details Article
PubMed
LigandPNGBDBM50245581(CHEMBL4092654)
Affinity DataIC50: 140nMAssay Description:Inhibition of PI3Kdelta in ACD-treated human whole blood assessed as reduction in IFNgammaX production measured after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2019
Entry Details Article
PubMed
LigandPNGBDBM50245581(CHEMBL4092654)
Affinity DataIC50: 290nMAssay Description:Inhibition of PI3Kdelta in ACD-treated human whole blood assessed as reduction in CD69 expression measured after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2019
Entry Details Article
PubMed