BDBM50247408 CHEMBL4067105

SMILES Oc1ccccc1C(=O)N\N=C\c1c(O)ccc2ccccc12

InChI Key InChIKey=ZZSJOLDICPVVAV-UHFFFAOYSA-N

Data  1 KI  3 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50247408   

TargetRibonucleoside-diphosphate reductase subunit M2(Human)
Case Western Reserve University

Curated by ChEMBL
LigandPNGBDBM50247408(CHEMBL4067105)
Affinity DataIC50: 1.23E+5nMAssay Description:Inhibition of human RRM2 expressed in Escherichia coli BL21-codon plus(DE3) using [14C]-ADP as substrate after 3 mins by liquid scintillation countin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2019
Entry Details Article
PubMed
TargetRibonucleoside-diphosphate reductase large subunit(Human)
Case Western Reserve University

Curated by ChEMBL
LigandPNGBDBM50247408(CHEMBL4067105)
Affinity DataKd:  3.70E+4nMAssay Description:Binding affinity to human RRM1 expressed in Escherichia coli BL21-codon plus(DE3)-RIL by fluorescence spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2019
Entry Details Article
PubMed
TargetRibonucleoside-diphosphate reductase large subunit(Human)
Case Western Reserve University

Curated by ChEMBL
LigandPNGBDBM50247408(CHEMBL4067105)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human RRM1 expressed in Escherichia coli BL21-codon plus(DE3)-RIL using [14C]-ADP as substrate after 3 mins by liquid scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2019
Entry Details Article
PubMed
TargetRibonucleoside-diphosphate reductase large subunit(Human)
Case Western Reserve University

Curated by ChEMBL
LigandPNGBDBM50247408(CHEMBL4067105)
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibition of human RRM1 expressed in Escherichia coli BL21-codon plus(DE3)-RIL using [14C]-ADP as substrate by boronate affinity chromatographyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2019
Entry Details Article
PubMed
TargetRibonucleoside-diphosphate reductase large subunit(Human)
Case Western Reserve University

Curated by ChEMBL
LigandPNGBDBM50247408(CHEMBL4067105)
Affinity DataKi:  5.00E+3nMAssay Description:Competitive inhibition of human RRM1 expressed in Escherichia coli BL21-codon plus(DE3)-RIL using [14C]-ADP as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2019
Entry Details Article
PubMed