BDBM50247983 CHEMBL454407::cis-1-methyl-5-(phenylethynyl)-3-(piperidin-1-ylmethyl)pyrrolidin-2-one

SMILES CN1[C@@H](C[C@H](CN2CCCCC2)C1=O)C#Cc1ccccc1

InChI Key InChIKey=VKXYLXZLODSKCD-UHFFFAOYSA-N

Data  4 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50247983   

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50247983(cis-1-methyl-5-(phenylethynyl)-3-(piperidin-1-ylme...)
Affinity DataIC50: 6.85E+3nMAssay Description:Inhibition of human ERG by patch-clamp techniqueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50247983(cis-1-methyl-5-(phenylethynyl)-3-(piperidin-1-ylme...)
Affinity DataEC50:  10nMAssay Description:Agonist activity at human recombinant alpha7 nAChR expressed in rat GH3 cells by calcium influx assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50247983(cis-1-methyl-5-(phenylethynyl)-3-(piperidin-1-ylme...)
Affinity DataIC50: 7.94E+3nMAssay Description:Antagonist activity at human alpha4beta2 nAChR expressed in HEK293 cells by calcium influx assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50247983(cis-1-methyl-5-(phenylethynyl)-3-(piperidin-1-ylme...)
Affinity DataIC50: 2.51E+5nMAssay Description:Antagonist activity at human 5HT3 receptor by calcium influx assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAcetylcholine receptor subunit alpha(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50247983(cis-1-methyl-5-(phenylethynyl)-3-(piperidin-1-ylme...)
Affinity DataIC50: 1.26E+4nMAssay Description:Antagonist activity at human alpha-1-beta-1-gamma-delta nAChR expressed in human TE671 cells by calcium influx assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed