BDBM50249818 3,6-Bis(dimethylamino)-9-(N-piperidyl-2-thienyl-5-thiocarboxamido)thioxanthylium Hexafluorophosphate::CHEMBL495469

SMILES CN(C)c1ccc2c(-c3ccc(s3)C(=S)N3CCCCC3)c3ccc(cc3sc2c1)=[N+](C)C

InChI Key InChIKey=JXTZWUHKOORUMQ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50249818   

TargetATP-dependent translocase ABCB1(Mouse)
The State University of New York

Curated by ChEMBL
LigandPNGBDBM50249818(3,6-Bis(dimethylamino)-9-(N-piperidyl-2-thienyl-5-...)
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibition of verapamil-stimulated ATPase activity of mouse cysteine-less MDR3More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
The State University of New York

Curated by ChEMBL
LigandPNGBDBM50249818(3,6-Bis(dimethylamino)-9-(N-piperidyl-2-thienyl-5-...)
Affinity DataIC50: 7.90E+3nMAssay Description:Inhibition of verapamil-stimulated ATPase activity of human histidine10-tagged MDR1 expressed in BHK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
The State University of New York

Curated by ChEMBL
LigandPNGBDBM50249818(3,6-Bis(dimethylamino)-9-(N-piperidyl-2-thienyl-5-...)
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of human MDR1 expressed in MDCK2 cells assessed as enhancement of Calcein-AM uptake treated 30 mins before Calcein-AM challenge measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed