BDBM50250191 3-acetyl-6-chloro-2-(2,4-dichlorophenylamino)-8-nitroquinolin-4(1H)-one::CHEMBL491348

SMILES CC(=O)c1c(Nc2ccc(Cl)cc2Cl)nc2c(cc(Cl)cc2c1O)[N+]([O-])=O

InChI Key InChIKey=RPOGXQPJVKMLKU-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50250191   

TargetCalpain-1 catalytic subunit(Human)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50250191(3-acetyl-6-chloro-2-(2,4-dichlorophenylamino)-8-ni...)
Affinity DataIC50: 4.64E+3nMAssay Description:Inhibition of human erythrocytes mu-calpain after 30 mins by fluorometric assay using pep1 as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetCalpain-1 catalytic subunit(Human)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50250191(3-acetyl-6-chloro-2-(2,4-dichlorophenylamino)-8-ni...)
Affinity DataIC50: 3.16E+3nMAssay Description:Inhibition of human erythrocytes mu-calpain by fluorometric assay using pep2 as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetCathepsin B(Human)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50250191(3-acetyl-6-chloro-2-(2,4-dichlorophenylamino)-8-ni...)
Affinity DataIC50: 1.27E+4nMAssay Description:Inhibition of human liver cathepsin B after 30 mins by fluorometric end-point assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50250191(3-acetyl-6-chloro-2-(2,4-dichlorophenylamino)-8-ni...)
Affinity DataIC50: 1.98E+4nMAssay Description:Inhibition of human liver cathepsin L after 30 mins by fluorometric end-point assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetPro-cathepsin H(Human)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50250191(3-acetyl-6-chloro-2-(2,4-dichlorophenylamino)-8-ni...)
Affinity DataIC50: 3.26E+4nMAssay Description:Inhibition of human liver cathepsin H after 30 mins by fluorometric end-point assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetCathepsin D(Human)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50250191(3-acetyl-6-chloro-2-(2,4-dichlorophenylamino)-8-ni...)
Affinity DataIC50: 42nMAssay Description:Inhibition of human liver cathepsin D after 30 mins by fluorometric end-point assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed