BDBM50250923 CHEMBL4072848::US10766883, Ex-3

SMILES COc1cc(Nc2nn(cc2C(N)=O)[C@H]2COCC[C@@H]2C#N)ccc1C#N

InChI Key InChIKey=ILEUVDWYQJSKJA-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50250923   

TargetTyrosine-protein kinase JAK1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50250923(CHEMBL4072848 | US10766883, Ex-3)
Affinity DataIC50: 0.0700nMAssay Description:Inhibition of GST-tagged recombinant human JAK1 catalytic domain expressed in baculovirus expression system using LCB-EQEDEPEGDYFEWLW-NH2 as substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50250923(CHEMBL4072848 | US10766883, Ex-3)
Affinity DataIC50: 0.0700nMAssay Description:The basic assay protocol is as follows: First, 250 nL of diluted compounds in DMSO were dispensed into the wells of a dry 384-well Black plate (Grein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50250923(CHEMBL4072848 | US10766883, Ex-3)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of JAK2 in EPO-stimulated human TF1 cells expressing stably integrated beta-lactamase reporter gene under control of STAT5 response elemen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50250923(CHEMBL4072848 | US10766883, Ex-3)
Affinity DataIC50: 3.28nMAssay Description:The basic assay protocol is as follows: First, 250 nL of diluted compounds in DMSO were dispensed into the wells of a dry 384-well Black plate (Grein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
US Patent

LigandPNGBDBM50250923(CHEMBL4072848 | US10766883, Ex-3)
Affinity DataIC50: 9nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human TYK2 catalytic domain expressed in baculovirus expression system using LCB-EQEDEPEGDYFEWLW-NH2 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50250923(CHEMBL4072848 | US10766883, Ex-3)
Affinity DataIC50: 19nMAssay Description:Inhibition of GST-tagged recombinant human JAK1 catalytic domain expressed in baculovirus expression system using LCB-EQEDEPEGDYFEWLW-NH2 as substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50250923(CHEMBL4072848 | US10766883, Ex-3)
Affinity DataIC50: 391nMAssay Description:Inhibition of GST-tagged recombinant human JAK3 catalytic domain expressed in baculovirus expression system using LCB-EQEDEPEGDYFEWLW-NH2 as substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50250923(CHEMBL4072848 | US10766883, Ex-3)
Affinity DataIC50: 430nMAssay Description:Inhibition of JAK2 in EPO-stimulated human TF1 cells expressing stably integrated beta-lactamase reporter gene under control of STAT5 response elemen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2019
Entry Details Article
PubMed