BDBM50250938 CHEMBL4088262

SMILES COc1ccnc2c(F)cc(Nc3nn(cc3C(N)=O)[C@H]3COCC[C@@H]3C#N)cc12

InChI Key InChIKey=VJDLSQUZAIIZIO-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50250938   

TargetTyrosine-protein kinase JAK1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50250938(CHEMBL4088262)
Affinity DataIC50: 0.190nMAssay Description:Inhibition of GST-tagged recombinant human JAK1 catalytic domain expressed in baculovirus expression system using LCB-EQEDEPEGDYFEWLW-NH2 as substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2019
Entry Details Article
PubMed
LigandPNGBDBM50250938(CHEMBL4088262)
Affinity DataIC50: 8nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human TYK2 catalytic domain expressed in baculovirus expression system using LCB-EQEDEPEGDYFEWLW-NH2 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50250938(CHEMBL4088262)
Affinity DataIC50: 10nMAssay Description:Inhibition of GST-tagged recombinant human JAK2 catalytic domain expressed in baculovirus expression system using LCB-EQEDEPEGDYFEWLW-NH2 as substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50250938(CHEMBL4088262)
Affinity DataIC50: 24nMAssay Description:Inhibition of JAK1 in IL6-stimulated human ME180 cells expressing stably integrated beta-lactamase reporter gene under control of sis-inducible eleme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50250938(CHEMBL4088262)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of GST-tagged recombinant human JAK3 catalytic domain expressed in baculovirus expression system using LCB-EQEDEPEGDYFEWLW-NH2 as substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50250938(CHEMBL4088262)
Affinity DataIC50: 2.11E+3nMAssay Description:Inhibition of JAK2 in EPO-stimulated human TF1 cells expressing stably integrated beta-lactamase reporter gene under control of STAT5 response elemen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2019
Entry Details Article
PubMed