BDBM50251974 CHEMBL482086::Cyclohexyl-{4-[4-(4-fluoro-phenyl)-2-methylsulfanyl-1H-imidazol-5-yl]-pyridin-2-yl}-amine

SMILES CSc1nc(c([nH]1)-c1ccc(F)cc1)-c1ccnc(NC2CCCCC2)c1

InChI Key InChIKey=GXEBQLXMNHUVPU-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50251974   

TargetMitogen-activated protein kinase 14(Human)
Eberhard-Karls-University Tu£Bingen

Curated by ChEMBL
LigandPNGBDBM50251974(Cyclohexyl-{4-[4-(4-fluoro-phenyl)-2-methylsulfany...)
Affinity DataIC50: 170nMAssay Description:Inhibition of p38 alpha MAPK in human whole blood assessed as suppression of LPS-induced TNF-alpha release by immunosorbent non-radioactive enzyme as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Eberhard-Karls-University Tu£Bingen

Curated by ChEMBL
LigandPNGBDBM50251974(Cyclohexyl-{4-[4-(4-fluoro-phenyl)-2-methylsulfany...)
Affinity DataIC50: 27nMAssay Description:Inhibition of p38 alpha MAPK in human whole blood assessed as phosphorylation of ATF-2 by immunosorbent non-radioactive enzyme assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Eberhard-Karls-University Tu£Bingen

Curated by ChEMBL
LigandPNGBDBM50251974(Cyclohexyl-{4-[4-(4-fluoro-phenyl)-2-methylsulfany...)
Affinity DataIC50: 20nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed