BDBM50252777 CHEMBL523374::N,6-Dimethyl-7-(1-((S)-3-methylmorpholino)phthalazin-6-yl)-benzo[d]isoxazol-3-amine

SMILES CNc1noc2c(c(C)ccc12)-c1ccc2c(nncc2c1)N1CCOC[C@@H]1C

InChI Key InChIKey=RXQPWAXTLUQACC-UHFFFAOYSA-N

Data  2 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50252777   

TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50252777(N,6-Dimethyl-7-(1-((S)-3-methylmorpholino)phthalaz...)
Affinity DataKi:  0.400nMAssay Description:Inhibition of human recombinant GST-tagged p38alphaMAPK-induced ATF2 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50252777(N,6-Dimethyl-7-(1-((S)-3-methylmorpholino)phthalaz...)
Affinity DataKi:  1.80nMAssay Description:Inhibition of human recombinant GST-tagged p38beta-induced ATF2 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50252777(N,6-Dimethyl-7-(1-((S)-3-methylmorpholino)phthalaz...)
Affinity DataIC50: 830nMAssay Description:Inhibition of PDGFRbetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50252777(N,6-Dimethyl-7-(1-((S)-3-methylmorpholino)phthalaz...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of c-KITMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50252777(N,6-Dimethyl-7-(1-((S)-3-methylmorpholino)phthalaz...)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of human ERG by manual electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50252777(N,6-Dimethyl-7-(1-((S)-3-methylmorpholino)phthalaz...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed