BDBM50253248 CHEMBL4102957

SMILES CNC(=O)c1nc(-c2nc(cnc2N)-c2cnc3ccccn23)n(C)n1

InChI Key InChIKey=YAQFEFFLEBSTDD-UHFFFAOYSA-N

Data  3 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50253248   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Astrazeneca

Curated by ChEMBL

LigandBDBM50253248(CHEMBL4102957)Copy SMILESCopy InChI

Affinity DataIC50: 20nMAssay Description:Inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/6/2019
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Astrazeneca

Curated by ChEMBL

LigandBDBM50253248(CHEMBL4102957)Copy SMILESCopy InChI

Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of PI3Kbeta (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/6/2019
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Astrazeneca

Curated by ChEMBL

LigandBDBM50253248(CHEMBL4102957)Copy SMILESCopy InChI

Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of PI3Kbeta in PTEN-deficient human MDA-MB-468 cells assessed as reduction in AKT phosphorylation at Ser473More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/6/2019
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL