BDBM50254705 CHEMBL4068633

SMILES [H][C@]12CCN(Cc3ccccc3F)C(=O)[C@@]1([H])[C@H](CC=C2)C(=O)Nc1ccc(C)c(c1)C(F)(F)F

InChI Key InChIKey=JMIJHHCCJXAAIY-UHFFFAOYSA-N

Data  1 KI  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50254705   

TargetKappa-type opioid receptor(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50254705(CHEMBL4068633)
Affinity DataEC50:  85nMAssay Description:Agonist activity at human kappa opioid receptor expressed in CHO cell membranes assessed as increase in [35S]-GTPgammaS binding after 1 hrs by TopCou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50254705(CHEMBL4068633)
Affinity DataKi:  85nMAssay Description:Agonist activity at human kappa opioid receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50254705(CHEMBL4068633)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human kappa opioid receptor expressed in CHO cells assessed as beta-arrestin2 recruitment by enzyme fragment complementation meth...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50254705(CHEMBL4068633)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human kappa opioid receptor expressed in human U2OS cells co-transfected with EFC and beta-arrestin-2 assessed as increase in bet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed