BDBM50254760 5-amino-N-(2-((2,6-difluoro-N-(2-hydroxyethyl)benzamido)methyl)-3,3,3-trifluoro-2-hydroxypropyl)-1-(4-fluorophenyl)-1H-pyrazole-4-carboxamide::CHEMBL517933

SMILES Nc1c(cnn1-c1ccc(F)cc1)C(=O)NCC(O)(CN(CCO)C(=O)c1c(F)cccc1F)C(F)(F)F

InChI Key InChIKey=DWMFXLXZBXBWJX-UHFFFAOYSA-N

Data  6 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50254760   

TargetGlucocorticoid receptor(Human)
Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50254760(5-amino-N-(2-((2,6-difluoro-N-(2-hydroxyethyl)benz...)
Affinity DataIC50: 15.8nMAssay Description:Displacement of fluorescent labelled Dexamethasone from glucocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50254760(5-amino-N-(2-((2,6-difluoro-N-(2-hydroxyethyl)benz...)
Affinity DataEC50:  50.1nMAssay Description:Agonist activity at human glucocorticoid receptor in human A549 cells assessed as transcriptional activity by MMTV luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50254760(5-amino-N-(2-((2,6-difluoro-N-(2-hydroxyethyl)benz...)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50254760(5-amino-N-(2-((2,6-difluoro-N-(2-hydroxyethyl)benz...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50254760(5-amino-N-(2-((2,6-difluoro-N-(2-hydroxyethyl)benz...)
Affinity DataIC50: 7.60E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50254760(5-amino-N-(2-((2,6-difluoro-N-(2-hydroxyethyl)benz...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50254760(5-amino-N-(2-((2,6-difluoro-N-(2-hydroxyethyl)benz...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed