BDBM50254851 3-Cyclohexyl-1-[4'-((3R,5S)-3,5-dimethyl-piperazin-1-ylmethyl)-biphenyl-2-ylmethyl]-1-[2-(3-methoxy-phenyl)-ethyl]-urea::3-cyclohexyl-1-((4'-(((3S,5R)-3,5-dimethylpiperazin-1-yl)methyl)biphenyl-2-yl)methyl)-1-(3-methoxyphenethyl)urea::CHEMBL501315

SMILES COc1cccc(CCN(Cc2ccccc2-c2ccc(CN3C[C@H](C)N[C@H](C)C3)cc2)C(=O)NC2CCCCC2)c1

InChI Key InChIKey=GNURRCJPQXKFTN-UHFFFAOYSA-N

Data  2 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50254851   

TargetCytochrome P450 3A4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50254851(3-cyclohexyl-1-((4'-(((3S,5R)-3,5-dimethylpiperazi...)
Affinity DataIC50: 200nMAssay Description:Inhibition of CYP3A4 using diethoxyfluorescein substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50254851(3-cyclohexyl-1-((4'-(((3S,5R)-3,5-dimethylpiperazi...)
Affinity DataIC50: 400nMAssay Description:Inhibition of CYP3A4 using phenyl-piperazinyl-methyl-benzyl-resofurin substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Rabbit)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50254851(3-cyclohexyl-1-((4'-(((3S,5R)-3,5-dimethylpiperazi...)
Affinity DataEC50:  126nMAssay Description:Activity at ghrelin receptor in New Zealand White rabbit gastric antral smooth muscle by calcium mobilization-based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetMotilin receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50254851(3-cyclohexyl-1-((4'-(((3S,5R)-3,5-dimethylpiperazi...)
Affinity DataEC50:  10nMAssay Description:Agonist activity at human recombinant motilin receptor expressed in CHO cells by calcium mobilization-based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetMotilin receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50254851(3-cyclohexyl-1-((4'-(((3S,5R)-3,5-dimethylpiperazi...)
Affinity DataEC50:  10nMAssay Description:Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMotilin receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50254851(3-cyclohexyl-1-((4'-(((3S,5R)-3,5-dimethylpiperazi...)
Affinity DataEC50:  50.1nMAssay Description:Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed