BDBM50255735 (+/-)-2-amino-N-(2-(4-(4-(methylthio)benzamido)piperidin-3-ylamino)-2-oxoethyl)-5-(trifluoromethyl)benzamide::CHEMBL481790

SMILES CSc1ccc(cc1)C(=O)NC1CCNCC1NC(=O)CNC(=O)c1cc(ccc1N)C(F)(F)F

InChI Key InChIKey=FUTBXMDGBHHNLB-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50255735   

TargetC-C chemokine receptor type 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50255735((+/-)-2-amino-N-(2-(4-(4-(methylthio)benzamido)pip...)
Affinity DataIC50: 12nMAssay Description:Binding affinity to wild type CCR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50255735((+/-)-2-amino-N-(2-(4-(4-(methylthio)benzamido)pip...)
Affinity DataIC50: 28nMAssay Description:Displacement of radiolabeled MCP1 from CCR2 in human PBMC by millipore filter plate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50255735((+/-)-2-amino-N-(2-(4-(4-(methylthio)benzamido)pip...)
Affinity DataIC50: 75nMAssay Description:Antagonist activity at CCR2 in human PBMC assessed as MCP1-induced calcium flux by fluorescence-imaging plate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50255735((+/-)-2-amino-N-(2-(4-(4-(methylthio)benzamido)pip...)
Affinity DataIC50: 109nMAssay Description:Antagonist activity at CCR2 in human PBMC assessed as MCP1-induced chemotaxisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetC-C chemokine receptor type 3(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50255735((+/-)-2-amino-N-(2-(4-(4-(methylthio)benzamido)pip...)
Affinity DataIC50: 19.7nMAssay Description:Inhibition of CCR3 at 10 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50255735((+/-)-2-amino-N-(2-(4-(4-(methylthio)benzamido)pip...)
Affinity DataIC50: 75nMAssay Description:Antagonist activity at CCR2 in human monocytes assessed as inhibition of MCP1-induced calcium influx by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50255735((+/-)-2-amino-N-(2-(4-(4-(methylthio)benzamido)pip...)
Affinity DataIC50: 28nMAssay Description:Displacement of [125I]MCP1 from CCR2 in human PBMCsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50255735((+/-)-2-amino-N-(2-(4-(4-(methylthio)benzamido)pip...)
Affinity DataIC50: 109nMAssay Description:Antagonist activity at CCR2 in human PBMCs assessed as inhibition of MCP1-induced chemotaxisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed