BDBM50256568 CHEMBL482150::N-[5-(methylsulfonyl)-1,3,4-thiadiazol-2-yl]sulfamide

SMILES CS(=O)(=O)c1nnc(NS(N)(=O)=O)s1

InChI Key InChIKey=JWUGIVSQNVELBH-UHFFFAOYSA-N

Data  5 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50256568   

TargetCarbonic anhydrase 1(Human)
Ecole Nationale Sup£Rieure De Chimie De Montpellier

Curated by ChEMBL
LigandPNGBDBM50256568(N-[5-(methylsulfonyl)-1,3,4-thiadiazol-2-yl]sulfam...)
Affinity DataKi:  103nMAssay Description:Inhibition of human recombinant cytosolic carbonic anhydrase 1 pre-incubated for 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Ecole Nationale Sup£Rieure De Chimie De Montpellier

Curated by ChEMBL
LigandPNGBDBM50256568(N-[5-(methylsulfonyl)-1,3,4-thiadiazol-2-yl]sulfam...)
Affinity DataKi:  940nMAssay Description:Inhibition of human recombinant cytosolic carbonic anhydrase 2 pre-incubated for 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 5B, mitochondrial(Human)
Ecole Nationale Sup£Rieure De Chimie De Montpellier

Curated by ChEMBL
LigandPNGBDBM50256568(N-[5-(methylsulfonyl)-1,3,4-thiadiazol-2-yl]sulfam...)
Affinity DataKi:  2.70E+3nMAssay Description:Inhibition of full length human recombinant mitochondrial carbonic anhydrase 5B preincubated for 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 4(Human)
Ecole Nationale Sup£Rieure De Chimie De Montpellier

Curated by ChEMBL
LigandPNGBDBM50256568(N-[5-(methylsulfonyl)-1,3,4-thiadiazol-2-yl]sulfam...)
Affinity DataKi:  6.10E+3nMAssay Description:Inhibition of truncated human cloned membrane-associated carbonic anhydrase 4 preincubated for 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 5A, mitochondrial(Human)
Ecole Nationale Sup£Rieure De Chimie De Montpellier

Curated by ChEMBL
LigandPNGBDBM50256568(N-[5-(methylsulfonyl)-1,3,4-thiadiazol-2-yl]sulfam...)
Affinity DataKi:  8.70E+3nMAssay Description:Inhibition of full length human recombinant mitochondrial carbonic anhydrase 5A pre-incubated for 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed