BDBM50256884 7-((4-(2-(4-tert-butylphenyl)-1H-benzo[d]imidazol-4-yl)piperazin-1-yl)methyl)quinoline::CHEMBL475660

SMILES CC(C)(C)c1ccc(cc1)-c1nc2c(cccc2[nH]1)N1CCN(Cc2ccc3cccnc3c2)CC1

InChI Key InChIKey=PMJQOTOFZRASBJ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50256884   

TargetGonadotropin-releasing hormone receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50256884(7-((4-(2-(4-tert-butylphenyl)-1H-benzo[d]imidazol-...)
Affinity DataIC50: 24nMAssay Description:Displacement of [D-Trp6]-GnRH from human recombinant GnRH receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50256884(7-((4-(2-(4-tert-butylphenyl)-1H-benzo[d]imidazol-...)
Affinity DataIC50: 140nMAssay Description:Antagonist activity at human GnRH receptor assessed as inhibition of [D-Trp6]-GnRH-stimulated [3H]IP reductionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Rat)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50256884(7-((4-(2-(4-tert-butylphenyl)-1H-benzo[d]imidazol-...)
Affinity DataIC50: 540nMAssay Description:Antagonist activity at rat recombinant GnRH receptor assessed as inhibition of [D-Trp6]-GnRH-stimulated LH release from rat pituitary cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed