BDBM50257602 CHEMBL4093792

SMILES Cc1ccc(Oc2ccc(cc2F)-c2ccn3c(CC(F)(F)F)nnc3c2Cl)c(C)n1

InChI Key InChIKey=HNBRTQIXHACHHR-UHFFFAOYSA-N

Data  1 KI  1 Kd  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50257602   

TargetMetabotropic glutamate receptor 2(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50257602(CHEMBL4093792)
Affinity DataKd:  3.30nMAssay Description:Binding affinity to human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50257602(CHEMBL4093792)
Affinity DataKi:  7.90nMAssay Description:Displacement of [3H]-JNJ46281222 from human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes after 60 mins by microbeta counting a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50257602(CHEMBL4093792)
Affinity DataEC50:  30nMAssay Description:Positive allosteric modulation of human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes assessed as increase in glutamate-induced...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2019
Entry Details Article
PubMed