BDBM50257654 CHEMBL492758::N-(1-(2-hydroxy-2-methylpropyl)-5-((phenylamino)methyl)-1H-benzo[d]imidazol-2(3H)-ylidene)-5-(2-methyloxazol-5-yl)thiophene-2-carboxamide

SMILES Cc1ncc(o1)-c1ccc(s1)C(=O)Nc1nc2cc(CNc3ccccc3)ccc2n1CC(C)(C)O

InChI Key InChIKey=BGMRBNOCQJRDMT-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50257654   

TargetTyrosine-protein kinase ITK/TSK(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50257654(N-(1-(2-hydroxy-2-methylpropyl)-5-((phenylamino)me...)
Affinity DataIC50: 11nMAssay Description:Binding affinity to ITK by DELFIA-based molecular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50257654(N-(1-(2-hydroxy-2-methylpropyl)-5-((phenylamino)me...)
Affinity DataIC50: 180nMAssay Description:Antagonist activity at human ITK expressed in BTK deficient DT40 cells assessed as inhibition of B cell receptor-stimulated calcium influxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50257654(N-(1-(2-hydroxy-2-methylpropyl)-5-((phenylamino)me...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of IRKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50257654(N-(1-(2-hydroxy-2-methylpropyl)-5-((phenylamino)me...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of ITK in presence of 1 mM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed