BDBM50257696 CHEMBL493318::N-(1-(2-hydroxy-2-methylpropyl)-5-((methyl(phenyl)amino)methyl)-1H-benzo[d]imidazol-2(3H)-ylidene)-5-(1H-pyrazol-4-yl)thiophene-2-carboxamide

SMILES CN(Cc1ccc2n(CC(C)(C)O)c(NC(=O)c3ccc(s3)-c3cn[nH]c3)nc2c1)c1ccccc1

InChI Key InChIKey=DYHYRTFULZNMOR-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50257696   

TargetTyrosine-protein kinase ITK/TSK(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50257696(N-(1-(2-hydroxy-2-methylpropyl)-5-((methyl(phenyl)...)
Affinity DataIC50: 8nMAssay Description:Binding affinity to ITK by DELFIA-based molecular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50257696(N-(1-(2-hydroxy-2-methylpropyl)-5-((methyl(phenyl)...)
Affinity DataIC50: 120nMAssay Description:Antagonist activity at human ITK expressed in BTK deficient DT40 cells assessed as inhibition of B cell receptor-stimulated calcium influxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50257696(N-(1-(2-hydroxy-2-methylpropyl)-5-((methyl(phenyl)...)
Affinity DataIC50: 780nMAssay Description:Inhibition of ITK in presence of 1 mM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50257696(N-(1-(2-hydroxy-2-methylpropyl)-5-((methyl(phenyl)...)
Affinity DataIC50: 5.50E+3nMAssay Description:Inhibition of IRKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed