BDBM50263007 CHEMBL4076827

SMILES C[C@H](CC(=O)Nc1cc(F)cnc1C)C(=O)N[C@H]1c2ccccc2CN2CCCN2C1=O

InChI Key InChIKey=RMAOZJWPQJSLBK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50263007   

TargetSignal peptide peptidase-like 2A(Human)
The Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50263007(CHEMBL4076827)
Affinity DataIC50: 44nMAssay Description:Inhibition of human SPPL2a expressed in human U2OS cells using EGFP-labeled TNFalpha (1 to 76 residues) NTF as substrate after 24 hrs by Hoechst stai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2020
Entry Details Article
PubMed
TargetSignal peptide peptidase-like 2A(Mouse)
The Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50263007(CHEMBL4076827)
Affinity DataIC50: 97nMAssay Description:Inhibition of mouse SPPL2a in A20 cells assessed as CD74/p8 accumulation by flow cytometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2020
Entry Details Article
PubMed
TargetSignal peptide peptidase-like 2A(Mouse)
The Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50263007(CHEMBL4076827)
Affinity DataIC50: 50nMAssay Description:Inhibition of SPPL2a in mouse whole blood assessed as increase in CD74/p8 accumulation after 5.5 hrs by Western bot methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2020
Entry Details Article
PubMed