BDBM50263331 (1H-Benzoimidazol-2-yl)-(R)-1,2,3,4-tetrahydronaphthalen-1-ylamine::(R)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1H-benzo[d]imidazol-2-amine::CHEMBL510780

SMILES c1ccc2c(c1)CCC[C@H]2Nc3[nH]c4ccccc4n3

InChI Key InChIKey=XZIZUQSOFMLIIR-UHFFFAOYSA-N

Data  1 KI  3 IC50  2 Kd  2 EC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50263331   

LigandPNGBDBM50263331((1H-Benzoimidazol-2-yl)-(R)-1,2,3,4-tetrahydronaph...)
Affinity DataKd:  77nMAssay Description:Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp techniqueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
LigandPNGBDBM50263331((1H-Benzoimidazol-2-yl)-(R)-1,2,3,4-tetrahydronaph...)
Affinity DataKd:  100nMAssay Description:Inhibition of wild type human SK3 channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
LigandPNGBDBM50263331((1H-Benzoimidazol-2-yl)-(R)-1,2,3,4-tetrahydronaph...)
Affinity DataEC50:  400nMAssay Description:Inhibition of wild type human SK3 channel expressed in HEK293 cells assessed as Ca2+ sensitivity by inside-out patch clamp techniqueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
LigandPNGBDBM50263331((1H-Benzoimidazol-2-yl)-(R)-1,2,3,4-tetrahydronaph...)
Affinity DataEC50:  2.20E+3nMAssay Description:Inhibition of wild type human SK3 channel expressed in HEK293 cells assessed as Ca2+ sensitivity by inside-out patch clamp technique in presence of 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 7(Mouse)
Huazhong University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50263331((1H-Benzoimidazol-2-yl)-(R)-1,2,3,4-tetrahydronaph...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of mouse TRPM7 transfected in HEK293 cells assessed as inhibition of channel current in absence of intracellular Mg2+ by whole cell patch ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTransient receptor potential cation channel subfamily M member 7(Mouse)
Huazhong University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50263331((1H-Benzoimidazol-2-yl)-(R)-1,2,3,4-tetrahydronaph...)
Affinity DataIC50: 5.90E+3nMAssay Description:Inhibition of mouse TRPM7 transfected in HEK293 cells assessed as inhibition of channel current in presence of 300 uM free intracellular Mg2+ by whol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTransient receptor potential cation channel subfamily M member 7(Mouse)
Huazhong University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50263331((1H-Benzoimidazol-2-yl)-(R)-1,2,3,4-tetrahydronaph...)
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of mouse TRPM7 transfected in HEK293 cells assessed as inhibition of channel current in presence of 780 uM free intracellular Mg2+ by whol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50263331((1H-Benzoimidazol-2-yl)-(R)-1,2,3,4-tetrahydronaph...)
Affinity DataKi: >5.00E+4nMAssay Description:Displacement of [I125]apamine from Wistar rat recombinant SK3 channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed